Three Genetic Alterations Linked to Higher Risk of Myeloma in African-Americans


Researchers have identified three genetic alterations associated with the known twofold to threefold risk of multiple myeloma among African-Americans.

The study, “Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry,” was published in the Blood Cancer Journal.

Multiple myeloma is the most common form of blood cancer affecting African-Americans, who can experience onset some four years earlier compared with European-Americans. But when African-American patients have access to proper care, they often have a better treatment response and overall survival than European-Americans.

These data suggest that African-Americans may have a genetic predisposition to specific types of multiple myeloma that are less aggressive or respond…

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