Tag Archives: Molecular

UCI researchers discover molecular mechanisms of an African folk medicine


IMAGE:¬†UCI researchers reveal how two components of the Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many…
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Credit: UCI School of Medicine/Geoff Abbott

Irvine, CA – November 14, 2018 – Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine used to treat a variety of illnesses and disorders including diabetes, pain, headaches, paralysis and epilepsy.

The herbal medicine, a leaf extract from the shrub Mallotus oppositifolius, has been used across Africa for centuries. Until now, the molecular mechanism was…

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Researchers discover molecular mechanisms of an African folk medicine


UCI researchers reveal how two components of the Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs, including the heart, kidneys, gastrointestinal tract, thyroid and pancreas. This computer model illustrates the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1. Credit: UCI School of Medicine/Geoff Abbott

Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine…

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Data from: Molecular and cytogenetic study of East African Highland Banana


Abstract

East African highland bananas (EAHB) are staple food crop in Uganda, Tanzania, Burundi and other countries in the African Great Lakes region. Even though several morphologically different types exist, all EAHB are triploid and display minimal genetic variation. To provide more insights into the genetic variation within EAHB, genotyping using simple sequence repeat (SSR) markers, molecular analysis of ITS1-5.8S-ITS2 region of ribosomal DNA locus and the analysis of chromosomal distribution of ribosomal DNA sequences was done. A total of 40 triploid EAHB accessions available in the Musa germplasm collection (International Transit Centre, Leuven, Belgium) were characterized. Six diploid accessions of Musa acuminata ssp. zebrina, ssp. banksii and ssp. malaccensis representing putative…

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African genetic diversity provides novel insights into evolutionary history and local adaptations | Human Molecular…


Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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