Tag Archives: genetic

Rapid genetic evolution linked to lighter skin pigmentation in a southern African population

Credit: CC0 Public Domain

Populations of indigenous people in southern Africa carry a gene that causes lighter skin, and scientists have now identified the rapid evolution of this gene in recent human history.

The gene that causes lighter skin pigmentation, SLC24A5, was introduced from eastern African to southern African populations just 2,000 years ago. Strong positive selection caused this gene to rise in frequency among some KhoeSan populations.

UC Davis anthropologist Brenna Henn and colleagues have shown that a gene for lighter skin spread rapidly among people in southern Africa in the last 2,000…

Read More

Three Genetic Alterations Linked to Higher Risk of Myeloma in African-Americans

Researchers have identified three genetic alterations associated with the known twofold to threefold risk of multiple myeloma among African-Americans.

The study, “Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry,” was published in the Blood Cancer Journal.

Multiple myeloma is the most common form of blood cancer affecting African-Americans, who can experience onset some four years earlier compared with European-Americans. But when African-American patients have access to proper care, they often have a better treatment response and overall survival than European-Americans.

These data suggest that African-Americans may have a genetic predisposition to specific types of multiple myeloma that are less aggressive or respond…

Read More

African American Living Donors’ Attitudes About APOL1 Genetic Testing: A Mixed Methods Study

Article in Press

Read More

Genetic Locus Linked to Migraine Risk in African American Children

MedicalResearch.com Interview with:
Hakon Hakonarson, MD, PhD
Corresponding Author
Xiao Chang, PhD
Lead Author
The Center for Applied Genomics
Children’s Hospital Philadelphia

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Migraine is a genetic disorder characterized by recurrent and intense headaches often accompanied by visual disturbances. Genome-wide association studies (GWASs) are a powerful hypothesis-free tool for investigating the genetic architecture of human disease. Currently, multiple GWASs have been conducted on European adults with migraine that have successfully identified several migraine susceptibility genes involved in neuronal and vascular functions.

Considering the prevalence of migraines varies…

Read More

Three Genetic Types Drive Higher Prevalence of MM in African Americans

Multiple myeloma (MM) occurs 2 to 3 times more frequently in Americans of African descent than in Americans of European descent, and a new study has identified 3 gene types that account for this disparity.

Multiple myeloma (MM) occurs 2 to 3 times more frequently in Americans of African descent than in Americans of European descent, and a new study1 has identified 3 gene types that account for this disparity.

The paper, published in Blood Cancer Journal, demonstrated that the disparity is largely driven by disparities in the occurrence of the t(11;14), t(14;16), and t(14;20) subtypes of MM.

“We sought to identify the mechanisms of this health disparity to help us better understand why myeloma occurs in the first place and provide insight into the best forms of therapy,” Vincent…

Read More

Phylogeography of African locust bean (Parkia biglobosa) reveals genetic divergence and spatially structured popula…

The evolutionary history of African savannah tree species is crucial for the management of their genetic resources. In this study, we investigated the phylogeography of Parkia biglobosa and its modelled distribution under past and present climate conditions. This tree species is very valued and widespread in West Africa, providing edible and medicinal products. A large sample of 1 610 individuals from 84 populations, distributed across 12 countries in Western and Central Africa, were genotyped using eight nuclear microsatellites. Individual-based assignments clearly distinguished three genetic clusters, extreme West Africa (EWA), centre of West Africa (CWA), and Central Africa (CA). Overall, estimates of genetic diversity were moderate to high, with lower values for populations in EWA (AR=6.4,…

Read More