Race Differences Seen in Alzheimer Biomarkers

Concentrations of tau protein and its phosphorylated isoform in cerebrospinal fluid (CSF) differed significantly between African-American and white individuals, researchers found.

Mean CSF concentrations of total tau were lower in African-American participants than in white participants (293.65 vs 443.28 pg/mL, P<0.001), as were mean concentrations of phosphorylated tau (53.18 vs 70.73 pg/mL, P<0.001), reported John Morris, MD, of the Washington University School of Medicine in St. Louis, and colleagues.

Only participants with an APOE ε4 allele showed these differences, suggesting a significant race-by-APOE ε4 interaction, they wrote in JAMA Neurology. There was no difference between African-American and white participants for…

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