High-Risk APOL1 Not Tied to CVD, Stroke in Older Black Women

July 09, 2018

High-risk APOL1 genotype is linked to HFpEF hospitalization in postmenopausal African-Americans.

HealthDay News — For postmenopausal African-American women, high-risk APOL1 genotype seems not to be associated with coronary heart disease, stroke, or mortality, according to a study published online July 3 in JAMA Cardiology.

Nora Fransceschini, MD, MPH, from the University of North Carolina in Chapel Hill, and colleagues used data from the Women’s Health Initiative to examine whether high-risk APOL1 genotypes are associated with cardiovascular disease and stroke in postmenopausal African-American women. APOL1 variants were genotyped or imputed from whole-exome sequencing. 

The researchers found that high-risk APOL1

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