Alzheimer’s Disease Biomarkers Differ in African-Americans and White Individuals

Action Points

  • Researchers found that African-American individuals who carried an APOE ε4 allele had significantly lower absolute levels of tau and phosphorylated tau in their CSF than their white counterparts, which suggests “a significant race-by-APOE ε4 interaction.”
  • The results of this study suggest that analyses of molecular biomarkers of AD should adjust for race, as the lower CSF of tau and phosphorylated tau in African-American individuals suggests that a differential effect of this…

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