African-American’s with prostate cancer respond better to radiation therapy than Caucasian men


Tumors from African-American men were found more likely to have low androgen receptor activity, indicating that the tumors were more likely to develop distant metastases within 10 years. However, tumors in the same population also had increased sensitivity to radiation therapy due to differences in gene expression compared to Caucasian men.  

“Differences in gene expression between African-American and Caucasian patients revealed that African-American patients had lower DNA repair and more immunogenic tumors, both of which have been shown to predict better responses to radiation therapy,” Spratt said. 

Secondly, the researchers examined outcomes from 5,854 patients (19.3 percent African-American) in four large randomized prostate cancer trials. In this…

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